The mission of the Society is to improve patient care and outcomes by facilitating implementation of functional assays into clinical care. The purposes are to foster research and development of functional precision medicine solutions across medicine; to accelerate the dissemination of new and relevant research findings among interested parties; to promote education and training about functional precision medicine; to foster solutions for clinical testing of functional precision medicine approaches; and to improve efficiency of adoption of functional precision medicine solutions through interaction with academia, regulatory bodies, industry, and patients.
March 13, 2020
Humans of Banbury: Interview with Christopher Kemp, PhD
Last month, the Banbury Center held its “CSHL Technology and Education Council: Challenges and Promise in Precision Medicine” meeting (February 18-20). During this time, I was able to meet with Christopher Kemp, Ph.D., and learn about the oncology research he performs and how he’s hoping to make a difference through it. Dr. Kemp, a Full Member at the Fred Hutchinson Cancer Research Center in Seattle, WA, received his doctorate in oncology from the University of Wisconsin–Madison.
February 28, 2020
Acute Myeloid Leukemia - Co-Authored by Board Member Jeff Tyner
Acute myeloid leukemia (AML) results from the enhanced proliferation and impaired differentiation of hematopoietic stem and progenitor cells. Using an ex vivo functional screening assay, we identified that the combination of the BTK inhibitor ibrutinib and BCL2 inhibitor venetoclax (IBR + VEN), currently in clinical trials for chronic lymphocytic leukemia (CLL), demonstrated enhanced efficacy on primary AML patient specimens, AML cell lines, and in a mouse xenograft model of AML.
February 27, 2020
Increased mitochondrial apoptotic priming with targeted therapy predicts clinical response to re-induction chemotherapy.
Most patients with relapsed or refractory (R/R) acute myeloid leukemia (AML) do not benefit from current re-induction or approved targeted therapies. In the absence of targetable genetic mutations, there is minimal guidance on optimal treatment selection particularly in the R/R setting highlighting an unmet need for clinically useful functional biomarkers. Blood and bone marrow samples from patients treated on two clinical trials were used to test the combination of lenalidomide (LEN) and MEC (mitoxantrone, etoposide, and cytarabine) chemotherapy in R/R AML patients.
January 06, 2020
Congratulations to our Board member Jeff Tyner!
Jeffrey Tyner, Ph.D., has received an Emerging Leader Award from @TheMarkFdn for Cancer Research. The award will support his research seeking combinations of anticancer agents able to stop #AML by targeting unique vulnerabilities among patients.
November 25, 2019
Congrats to our board member Sara Cherry on receiving the Stanley N. Cohen Biomedical Research Award!
Congratulations to Sara Cherry on her well-deserved Penn Medicine Stanley N. Cohen Biomedical Research Award! In recognition of an outstanding body of work in Biomedical Research!
November 08, 2019
Dynamic Tumor Cell Profiling Technique Correlates With Therapy Responses
A technique involving BH3 profiling is emerging as a promising drug discovery tool for assessing whether a tumor is primed for cell death and would respond to anticancer therapy, according to a presentation at the 2019 Association for Molecular Pathology Annual Meeting.
October 01, 2019
Christopher Kemp and Carla Grandori: The Promise of Functional Precision Medicine
Remarkable advances in genomic profiling of tumors have not translated easily into effective personalized therapies for many patients. Functional precision medicine brings forward an alternative approach, one where the drug-sensitivity phenotype of individual tumors is layered onto the genotype information. Christopher Kemp hail- ing from the Fred Hutchinson Cancer Research Center in Seattle, and Carla Grandori jointly founded Cure First and SEngine Precision Medicine, organizations that are advancing the implementation of cancer functional testing. Here they discuss the chal- lenges and multiple opportunities lying ahead to enable the adoption of functional approaches to precision therapy in oncology.